One of the studies that has attracted the most attention at the 2014 American Society of Clinical Oncology Annual Meeting and in the media covering the meeting is a phase III trial that found giving a woman with hormone receptor negative (ER- and PR-) breast cancer goserelin (Zoladex), a drug that temporarily shuts down the ovaries, increased the odds that her ovaries would resume functioning after she completed treatment. Of the 218 women studied, 22% of those who had chemotherapy alone experienced ovarian shutdown caused by the drugs compared to 8% of the women who took Zoladex along with chemotherapy. There were 13 pregnancies among the women who had chemotherapy alone and 22 among the women who had chemotherapy and Zoladex.

Knowing that chemotherapy may keep you from being able to have a child, or more children, has often been one of the more emotionally challenging aspects of breast cancer treatment for premenopausal women. (The problem is that chemotherapy can be toxic to the eggs or put a woman into premature menopause.) Over the past five years, advocacy groups have worked hard to increase awareness about the importance of doctors talking to young cancer patients about fertility and making women aware of options like egg and embryo freezing that might help them have a child after their treatment ends. Now, women with hormone-negative tumors have a new option to talk over with their doctors: using Zoladex to protect their ovaries from chemo.

Taking Zoladex cannot guarantee chemotherapy won’t affect the ovaries. The study found that Zoladex reduced the risk of women going into premature menopause, but most of the women still did. There is currently no way to know which women are most likely to benefit from Zoladex and which will not. That said, I would encourage women who are premenopausal, have hormone-negative tumors, and are hoping to have a child after chemotherapy to talk to their doctors about this option.

You may also have heard that the researchers presented findings from an exploratory analysis that showed the women who took Zoladex appeared to have improved disease-free survival and overall survival. The researchers didn’t set up the study to look at survival, and their exploratory analysis suggests that more studies should be done to see if it is beneficial. It does not tell us that Zoladex improves survival in women with hormone-negative tumors.

Another group of researchers presented findings from two studies that looked at the use of ovarian suppression in premenopausal women with hormone receptor positive breast cancer. At the time this study was started, premenopausal women with hormone-sensitive tumors would take tamoxifen for at least five years following breast cancer surgery. But postmenopausal women were now taking aromatase inhibitors because studies had found that they were more effective for them than tamoxifen.

(Tamoxifen blocks the estrogen receptor on the cancer cells, preventing them from growing, and can be used by pre- or postmenopausal women. Once a woman goes into menopause the ovaries stop producing estrogen; but they continue to produce a precursor that the breast and other organs can convert into estrogen by using an enzyme called aromatase. The aromatase inhibitors block this enzyme. For this reason, only women who are in menopause or who have been put into temporary menopause can take an aromatase inhibitor.)

So, studies were designed to look at whether the aromatase inhibitors would be better for premenopausal women. But for a premenopausal woman to take an aromatase inhibitor, she’d first have to be put into temporary or permanent menopause. In these studies, ovarian suppression could have been through a drug (in this case, the drug triptorelin was used), oophorectomy (removal of the ovaries), or ovarian radiation. Then, women were given five years of tamoxifen or the aromatase inhibitor exemestane (Aromasin). After following the women for five years, disease-free survival among the women in the Aromasin group was 91.1% compared to 87.3% for those taking tamoxifen.

As a champion of talking about collateral damage, I would be remiss if I did not point out that the side effects were about the same in both groups. So, while the small benefit of using an aromatase inhibitor instead of tamoxifen is real, some women may decide it is not worth it for them and they should know tamoxifen remains another option.

As the hormonal options for women with estrogen positive cancers increase, it can make deciding on a treatment more difficult.  It is important for women to know that there are options. Studies are designed to determine the “best” treatment. But the best treatment for you will be the one that does not sacrifice the quality of your life for a small statistical advantage. Each woman will have to have a discussion with her physician to determine the right approach for her.

Share →

32 Responses to Breast Cancer Treatments That Shut Down the Ovaries: What you need to know

  1. World osteoporosis day orthomol osteo In my opinion you commit an error, let’s discuss. Write to me in PM, we will communicate.

  2. Cle says:

    I just now would not depart your website just before hinting i always particularly relished the typical information an individual deliver on your family and friends? Will probably be yet again constantly to think about fresh blogposts

  3. Regan says:

    This is the right website for everyone who hopes to find out about this topic.
    You understand a whole lot its almost tough to argue with you (not that I actually will need to…HaHa).

    You definitely put a fresh spin on a topic that’s been discussed for many years.
    Wonderful stuff, just great!

  4. Hey there I am so thrilled I found your blog page, I really found you by
    error, while I was searching on Askjeeve for something
    else, Anyhow I am here now and would just like to say many thanks for
    a marvelous post and a all round entertaining
    blog (I also love the theme/design), I don’t have time to read
    through it all at the minute but I have bookmarked it and also added your RSS feeds, so when I have time I will be back to
    read a lot more, Please do keep up the superb work.

  5. Girl, 28 tu??, tính tình vui v?, hi?n d?u, công vi?c ?n ??nh mu?n tìm b?n trai ? TP Ninh Bình ?? tìm
    hi?u và ti?n ??n hôn nhân.R?t ong ???c làm quen v?i các b?n có ý ??nh nghiêm túc.

  6. David says:

    Unquestionably believe that which you said. Your favorite justification appeared to be on the web
    the simplest thing to be aware of. I say to you, I definitely
    get irked while people think about worries that they just do not know about.
    You managed to hit the nail upon the top and also defined out the whole
    thing without having side-effects , people could take a signal.
    Will likely be back to get more. Thanks

  7. seksitreffit says:

    Hi there it’s me, I am also visiting this web site daily, this website is actually pleasant and the users are
    actually sharing nice thoughts.

  8. Quality content is the important to attract the viewers to pay a visit the
    site, that’s what this site is providing.

  9. The initial problem which many companies face when they
    are using both WordPress as well as Code – Igniter is
    when they want to incorporate Code – Igniter
    functionality into their WordPress theme files.
    Benefits of the framework include secure communication, business
    management tools, mobile app creation and multi-platform compatibility.
    ” The GNUpdf library has, however, not been released yet, while Poppler has enjoyed wider use in applications such as Evince, which comes with the GNOME desktop environment, at the expense of relying on the GPLv2-licensed Xpdf code base that can’t be used by GPLv3 programs.

  10. I am really enjoying the theme/design of your site.
    Do you ever run into any browser compatibility issues? A number of my blog readers have complained about my site not operating correctly in Explorer but looks great in Chrome.
    Do you have any recommendations to help fix this problem?

  11. I think this is one of the most significant info for me.
    And i am glad reading your article. But should remark on some general things, The website style
    is great, the articles is really excellent : D.

    Good job, cheers

  12. Thanks for the marvelous posting! I actually enjoyed reading it, you can be a
    great author.I will make certain to bookmark your blog and will come back sometime soon. I want to encourage you
    continue your great writing, have a nice morning!

  13. tutaj says:

    Hi there, yeah this piece of writing is in fact fastidious and I have learned lot of
    things from it regarding blogging. thanks.

  14. Write more, thats all I have to say. Literally, it seems as though you reliesd on thhe video to make your point.
    You obviously know what yyoure taling about, why throw away your intelligence on just posting videois tto your weblog when you could be giving us something informative to read?

  15. Stream says:

    I hope sooner or later we will find the treatment for the cancer

  16. says:

    The dedicated team of AVG professionals can be acquired
    here all round time, whom it is possible to reach by calling
    on the AVG tech support number. She invites you to visit her site where she is going to share a proven method to start an internet business.
    A well-developed business plan is a lot like your blueprint for victory.

    My web blog …

  17. Just desire to say your article is as astounding.

    The clearness in your submit is simply nice and i can suppose
    you’re a professional on this subject. Fine wwith your permission let me to take hold of your feed to keep up to
    date woth impending post. Thank you one million and ppease continue
    the gratifying work.

  18. smartphone says:

    Now, a United Nations report released this week offers
    the highest-profile, international attempt to investigate those claims.
    Alerts and RSS feeds are also considered important drivers to steer the consumer again and again to your portal.
    So many cases have very attractive designs that can help you to give your cell phone a facelift.

  19. I simply couldn’t go away your website prior to suggesting that I extremely enjoyed the usual info a person supply on your visitors?
    Is going to be again continuously to check up on new

  20. hotgirl says:

    It is also good to have a good conversation with waitresses and make them laugh.
    They promise to teach you how to score with the female that turns every head
    when she walks by. Do you absolutely have what it
    takes to discover the basics of how to date hot ladies.

  21. The Click URL is where you enter the link for the banner.
    The size and shape of the bumper sticker is amongst the top needs.
    There are lots of savings that you can do once you hire offshore expert Joomla web development and Content Management System for Joomla development, as you do not need to possess any infrastructure to place your hired expert Joomla developer programmer, you can save of lots of taxes that
    need to be paid to hold certain amount of in-house
    employees and the infrastructure for the same.

    Feel free to visit my web page: joomla hosting requirements

  22. Micro-DVI ports can transmit only digital video signals, as opposed to help Mini-DVI ports, which can send both digital
    and analog video signals. The speaker bar above its
    keyboard produces acceptable audio best.

    My web site case for macbook pro 13, repair macbook, discount macbook pro, cell phone repair,comprar online

  23. Marylin says:

    Hello there! I could have sworn I’ve been to your blog before but after looking
    at a few of the posts I realized it’s new to me. Anyhow, I’m certainly delighted
    I discovered it and I’ll be book-marking it and checking back regularly!

  24. New Balance Rc410 New Balance 373 Homme YQtpa Fortunatamente, questo è noioso, non vengono in mente quando si
    descrive 100 anni dopo la creazione del gioco giocato.
    Nel febbraio dello scorso anno, quando il relativamente sconosciuto giovane
    Dee Brown, Boston Celtics, rimosso, e chinò la Reebok
    Pompe di vincere il 1992 NBA Slam Dunk Contest con brio e l’entusiasmo di mettere la palla oltre la rete, una nuova stella nel cuore collettivo
    impulso da corsa d’America promette una nuova una
    partita di basket e un nuovo secolo. New Balance Minimus New Balance Mt580
    AjWzG Ora Keane società americana, utilizzare questo materiale di base, producendo una serie di Harvest collezione borse.
    Ad esempio, una borsa di nome Cornell, hanno introdotto
    una borsa messenger unisex è realizzata al 100% in carta riciclata del riso,
    come il fondo è realizzato in 100% gomma riciclata, la borsa davvero confortevole, unico e verde..
    New Balance 480 New Balance Femme Running NYfMJ Nel terzo trimestre, l’allenatore
    ha visto aumento delle vendite internazionali del 6% a $
    382.000.000. Adeguamento per effetto cambio, il fatturato sarebbe aumentato del 14%.

    New Balance Custom New Balance France NfkkV Alex decide
    che prenderà il discorso di capelli con Jim Johnson, che, pur avendo inserito l’azienda nel modo
    più sfortunato, ha fatto un ottimo lavoro Bailey, Twisden, Kaufman, e Chang.
    Si tratta di due settimane dopo il rilascio di improvviso furriness di Leslie, interrotta ha preso così tanto tempo per Alex a mettere
    da parte il loro desiderio di distanza sociale da sconveniente e fastidioso Jim Johnson, e
    quando Alex fa una lunga passeggiata attraverso il vetro e mogano corridoi della sua
    azienda per Johnson armadio glorificato, in un’ala del mandato di
    agenzia che Alex malapena hanno visitato prima, egli è informato da una donna di nome Betty Varrick, un assistente legale (e segretario), diviso per cinque giovani avvocati della società, che la signora Johnson ha avuto un bambino e il signor Johnson non e ‘stato in carica dal..
    New Balance Pas Cher Newbalance.Com IkNIt Ho avuto i miei primi stivali Ugg durare per
    diverse ore e sono gonfiore, prurito e sensazione di bruciore sulla pianta dei miei piedi.
    Io non sarò più in grado di indossare gli stivali.

    New Balance 577 New Balance Pas Chere krOky E ‘inoltre in barca sul look È possibile utilizzare molti anni di scrittura e non lasciare la tua
    moda. Il Sorel Caribou IMR 1 maggio seamsealed pelle impermeabile superiore.
    New Balance London New Balance 570 CCLjW Oppure, se si vuole fare una donazione in denaro può ottenere elenchi e rifornirsi.
    Potremmo anche raccogliere le donazioni a casa tua, e io ei
    miei amici lavoreremo per ottenere insieme uno sforzo così tante borse libro di noi..
    New Balance U420 Femme New Balance 573 QsfeY La casa è stata condannata 25 aprile da parte dei funzionari township dopo che la polizia
    andò a casa la sera prima. Essi stavano rispondendo ad una denuncia presentata da una donna di Taylor che aveva dato
    la casa s residente due gatti da allevamento,
    ed erano venuti a comprare un altro gatto..

  25. I used to work as a content material writer and was learning about Search Engine Optimisation in an web marketing agency.

  26. Thelma says:

    Hi, i believe that i saw you visited my blog thus
    i got here to return the favor?.I’m trying to find things to enhance my web site!I guess its ok to use a few of your ideas!!

    My web-site homepage; Thelma,

  27. It’s the best time to make some plans for the long run and it’s time to be happy.
    I’ve learn this submit and if I could I wish to recommend you few interesting issues or
    suggestions. Maybe you can write next articles referring to this article.
    I want to read even more things about it!

  28. Fine way of explaining, and fastidious piece of writing to get facts about my presentation topic, which i
    am going to present in academy.

  29. Wonderful blog! Do you have any suggestions for aspiring
    writers? I’m planning to start my own website soon but I’m a little lost
    on everything. Would you propose starting with a free platform like WordPress or go for a paid option? There are so many options out there that I’m completely confused ..
    Any tips? Many thanks!

  30. Try extending your features by creating your personal custom tabs.

  31. It’s hard to come by experienced people for this topic,
    but you sound like you know what you’re talking about! Thanks

  32. May I just say what a relief to discover an individual
    who really understands what they’re discussing online.
    You actually know how to bring an issue to light and make it important.
    More and more people need to look at this and understand this side of your story.

    It’s surprising you are not more popular because you surely possess the gift.

Leave a Reply

Your email address will not be published. Required fields are marked *

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>